Scientists from Stanford University have stated that they managed to completely destroy cancerous tumors in laboratory mice by injection of two drugs that stimulate the immune system of the body.
Scientists have combined two types of compounds. First — CpG-oligonucleotide (short DNA fragment), which connects with the toll-like receptor 9 (TLR9). TLR9 enhances the expression of OX40 receptor on T-lymphocytes: the receptors provides the division and survival of T cells and production of cytokines and peptide molecules that regulate interactions between cells. The second agent of the drug — antibodies to the receptor OX40. This component stimulates the activity of T-cells, causing it to attack the tumor. Since the “mixture” is introduced into the tumor, substances trigger the T-cells associated with it. For a single injection should be about micrograms of the drug.
The tests used 90 of mice in the body which artificially imposed the lymphoma cells. Each mouse formed two tumors in the right and left shoulder. The animals received injections in one of the tumors. After injection of the tumor began to lessen, for 87 of the 90 animals the treatment was successful on the first attempt. At the same decreased not only tumor that was injected, but the second, unaffected. The three remaining mice, the treatment helped with the second attempt. Further experiments showed that the method works for mice with melanoma and tumors of the breast and colon.
In the future, the researchers intend to repeat the experiment on humans, reports zn.ua.