Researchers have learned how to edit a blood transfusion
Biologists from Bristol University are one step closer to the edit blood for patients with rare blood groups.
Researchers have introduced a technology that helps to produce blood cells for transfusion to those patients for whom there was no donor, says Science Alert.
Research Ashley Toya and his colleagues from the University of Bristol in the UK showed that with the help of technology CRISPR can be removed from the cells genes of rare blood groups.
Different blood group of different people is determined by the presence or absence of the so-called antigens on the surface of red blood cells. When it comes to blood transfusions, it is important to take into account the blood group. There are 36 different systems of blood groups, which klassificeret more than 350 antigens that appear on red blood cells in various combinations. A blood transfusion from an incompatible donor leads to the immune response that causes the destruction of red blood cells, and can be life-threatening.
The new mechanism has the same function as “find and replace”: the enzyme Cas9 cuts the DNA in the place chosen for the sample. Then specific genes that can cause immune reactions, are removed. It has the potential to help patients with these congenital diseases like thalassemia and sickle cell anemia.
Scientists are still far from growing blood cells in the lab in large enough quantities to use them for blood transfusions. However, once technical obstacles are overcome, the first recipients of such cells is likely to be patients who find it difficult or impossible to find a donor. A new study shows that it is now possible to adapt the antigenic profile of the cell lines of blood to the needs of these patients.
In 2017 NV reported that biologists from the University of Bristol have developed a technique that allows you to get unlimited amount of red blood cells from stem cells. The new method is to grow a kind of “immature” red blood cells, that is, to stop the process in its early stages.